Fire and Mello shared the 2006 Nobel Prize in Physiology or Medicine for their work in unraveling the mechanism of what has come to be known as RNA interference. They studied RNAi in C. elegans, also known as roundworms. I ran across this animation video via GrrlScientist who saw it posted on YouTube by megh2748. The video originates from Nature Reviews, RNA interference animation library. I mean, come on. How could you not love a mechanism that involves enzymes called Dicer and Slicer and complexes called RISC?